But Benjamin Bourigeaud's stunning strike, which flew into the top right corner, levelled matters immediately after Sokratis Papastathopoulos' dismissal for a second booking.
And Ismaila Sarr's diving header in the closing stages compounded a miserable evening for Arsenal.
However, it was no more than the hosts deserved as they capitalised on their man advantage to bombard the visiting goal after the break.
Arsenal will now hope to repeat their heroics from the last-32 stage, where they overturned a 1-0 first-leg deficit against Belarus side Bate Borisov to progress with a 3-0 home victory. SHARE THIS STORY USING ANY OF THE BUTTON BELOW ⬇ PLACE YOUR TEXT ADVERT BELOW ⬇⬇⬇