Liverpool’s victory over Bournemouth on Saturday has propelled the Reds back to the top of the standings, but Pep Guardiola’s men can leapfrog them with a home win, albeit having played a game more.
Meanwhile, Chelsea, whose Europa League challenge starts anew in midweek, have slipped out of the top four and need at least a draw to jump resurgent Manchester United.
Position Manchester City squad
Goalkeepers Ederson, Muric
Defenders Stones, Laporte, Otamendi, Mangala, Sandler, Zinchenko, Walker, Danilo
Midfielders Fernandinho, Gundogan, Foden, Delph, De Bruyne, D. Silva
Forwards Sane, Sterling, B. Silva, Mahrez, Aguero, Jesus
Benjamin Mendy will not play this weekend and has not featured since knee surgery early in the season.
Raheem Sterling and Leroy Sane should both be recalled, while Pep Guardiola has hinted Kevin De Bruyne could be benched.
Vincent Kompany and Claudio Bravo remain sidelined, but otherwise Pep Guardiola has a full squad of players to pick from.
Possible Manchester City starting XI: Ederson; Walker, Stones, Laporte, Danilo; De Bruyne, Fernandinho, D. Silva; Sterling, Aguero, Sane
Position Chelsea players
Goalkeepers Arrizabalaga, Caballero, Green
Defenders Azpilicueta, Zappacosta, Rudiger, Luiz, Cahill, Ampadu, Emerson
Midfielders Jorginho, Drinkwater, Kante, Barkley, Loftus-Cheek, Kovacic
Forwards Willian, Pedro, Hazard, Giroud, Hudson-Odoi, Higuain
Chelsea manager Maurizio Sarri has no selection headaches before this game, in which he will deploy his strongest XI. He has said it is possible that Eden Hazard will play in a false 9 role.
Changes will be reserved for the Europa League encounter with Malmo in Sweden on Thursday.
Possible Chelsea starting XI: Kepa; Azpilicueta, Christensen, David Luiz, Alonso; Kante, Jorginho, Kovacic; Willian, Higuain, Hazard
Betting & Match Odds
Manchester City are 1/2 to take maximum points with Bet365, while Chelsea can be backed at 6/1. A draw is priced at 18/5. SHARE THIS STORY USING ANY OF THE BUTTON BELOW ⬇ PLACE YOUR TEXT ADVERT BELOW ⬇⬇⬇