Teammates David Silva, Riyad Mahrez and Kyle Walker have all dropped to the bench, but the fact Aguero was not even included in the squad raised a few eyebrows.
But manager Pep Guardiola says he has a "muscular dsturbance", while sources at City say that he has been feeling a slight problem, which was not an injury but caused enough concern for the decision to be taken to leave him out.
That means Gabriel Jesus steps back into the starting line-up after passing a late fitness test on a problem which saw him miss the Champions League game in France.
Bernardo Silva and Ilkay Gundogan, who also did not travel to Lyon, also passed fitness tests and start. SHARE THIS STORY USING ANY OF THE BUTTON BELOW ⬇ PLACE YOUR TEXT ADVERT BELOW ⬇⬇⬇