Eric Bailly is set to return to the starting line-up for the first time since November.
Ander Herrera, Daley Blind and Marouane Fellaini remain sidelined while Zlatan Ibrahimovic could make the bench as he continues to search for full fitness after last year ligament injury.
Marcos Rojo faces a late fitness test with a knock while Phil Jones remains a doubt for the clash.
Romelu Lukaku and Alexis Sanchez will start but to complete an attacking trio, Juan Mata, Marcus Rashford and Jesse Lingard will have to fight for the last spot.
United have been in superb form at home losing only one this season in all competition with the lose being the one against rival Manchester City.
However, Jurgen Klopp’s Liverpool will miss Nathaniel Clyne who came back from injury and featured for the Under-23s but remain unavailable for first-team selection.
Alex Oxlade-Chamberlain will return to the starting XI after being rested against Porto in the week.
Georginio Wijnaldum is ill and may not play while captain Henderson is a doubt with a leg injury but could be a surprise inclusion.
Liverpool have lost just once in their last 20 Premier League matches against United, winning 14 and drawing 5.
The Reds have also won their last three away games in a row, scoring 10 goals.
Manchester United potential starting XI: De Gea; Valencia, Bailly, Smalling, Young; McTominay, Matic, Pogba; Lingard, Lukaku, Alexis.
Liverpool potential starting XI: Karius; Alexander-Arnold, Matip, Van Dijk, Robertson; Oxlade-Chamberlain, Henderson, Can; Salah, Firmino, Mane.
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