November's original fight was postponed after Ortiz failed a drug test.
Ortiz was fined $25,000 (£18,497) but not banned from the sport as the World Boxing Council said the Cuban took the drugs for high blood pressure.
American Wilder has won all 39 of his professional fights, all but one inside the distance. Ortiz has won all 28.
Britain's Anthony Joshua, who holds the IBF and WBA world heavyweight belts, is in talks with WBO champion Joseph Parker of New Zealand over a potential fight at Cardiff's Principality Stadium on 31 March.
No boxer has simultaneously held the WBC, IBF, WBA and WBO world heavyweight belts, and Wilder is a future target for Joshua.
When the original fight with 38-year-old Ortiz was postponed, Wilder then defended his WBC title against Canadian Bermane Stiverne and won with a first-round knockout.
On Thursday, it was announced that Wilder was ordered to do 60 hours of community service after being found guilty of misdemeanour marijuana possession after he was arrested in Alabama last June.
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