Former Everton winger Gerard Deulofeu, Sergio Busquets, Lionel Messi, Luis Suarez and Denis Suarez all scored.
Chapecoense were captained in Monday's friendly by Alan Ruschel, one of only three players to survive the crash, on his return to action.
It was Barca's first home game since Ernesto Valverde took over as boss.
Valverde, 53, has succeeded Luis Enrique, who stepped down at the end of last season.
It was also the Catalan club's first game since Brazil forward Neymar left to join French club Paris St-Germain for a world record fee of 222m euros (£200m).
The annual invitational game is traditionally where Barcelona unveil their team for the new season to home fans and the winners received the Joan Gamper Trophy.
Chapecoense signed 25 new players this season and promoted nine from the youth team.
The crash happened as Chapecoense were travelling to face Colombian side Atletico Nacional in the final of the Copa Sudamericana.
READ MORE PLACE YOUR TEXT ADVERT BELOW:>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> How I Made Me =N=2.5 MILLION In 7 Days from 2 Common Product I Imported and how you can do the same. Click HERE FOR FREE Details right now Warning To Men: This 3 Foods Is Killing Your Erection. Click Here To Know Them Secret Fruits that increased my Manhood and makes me last 55 minutes+ all time - Click here to get it Warning: Got Arthritis? 3 Simple Ways To Get Cured And Be Permanently Free From Joint Pains. Click Here To See Them REVEALED!! Reduce Your Blood Sugar Level And Reverse Diabetics Within A Short Period Of Time. Click Here To See How MIDNIGHT,Pressed Mr Kilanko Suddenly Couldn't Urinate. Shrink your Enlarged Prostrate Here! Click Here Now