The reality star, 35, was threatened by five armed masked me dressed as police officers.
Kardashian had jewellery worth millions of dollars stolen, according to reports.
Her spokesperson said she is "badly shaken but physically unharmed".
The incident is believed to have happened at around 3am on Monday at a "luxury residence" in the 8th arrondissement of Paris.
The district sits on the River Seine and is centred on the Champs-Elysees.
Kardashian's superstar husband Kanye West was performing a gig almost 6,000 miles away in New York, but suddenly walked off stage stating he had a "family emergency".
The rapper was performing at the Meadows Festival in Queens.
Kim Kardashian's spokesperson Ina Treciokas said: "Kim Kardashian West was held up at gunpoint inside her Paris hotel room this evening, by two armed masked men dressed as police officers.
"She is badly shaken but physically unharmed."
Kim has been enjoying in France enjoying Paris Fashion Week with older sister Kourtney and mum Kim and has been spotted front row at runways shows including Balenciaga, Givenchy and Balmain.
She had children Saint, nine months, and North, three years, but they were not in the hotel room at the time of the incident, according to People.
West was mid-way a performance of his song 'Heartless' when he stopped abruptly, fans said.
This was around 10.45pm local time in New York and 4.45am in France.
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